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American Journal of Physiology-Cell Physiology theme: ion channelsand transporters in cancer
From Annarosa Arcangeli1 and Jason X.-J. Yuan2
IN THIS ISSUE, the American Journal of Physiology-Cell Physiology
initiates the publication of a new Theme series of review
articles that focus on the pathogenic role of ion channels and
transporters in cancer. Ion channels, as an important family of
membrane proteins that are highly expressed in virtually all
types of cells, not only regulate cell excitability, muscle contraction,
and glandular secretion. Activity of various ion
channels in the plasma membrane and intracellular organelle
membranes also plays an important role in regulating cell
proliferation, migration, apoptosis and differentiation, cellular
functions, and processes that are traditionally considered
to be regulated by intracellular signaling proteins and
transcription factors. We hope that this series of reviews
will bring to readers a new concept regarding the potential
role of ion channels in cancer and help provide a rationale
for the targeting of ion channels and their chaperones as a
new approach for the treatment of cancer
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