运动期间患2型糖尿病的老人储存更多的热量

仰望苍穹

Introduction: It is unknown if diabetes-related reductions in local skinblood flow (SkBF) and sweating (LSR) measured during passive heat stresstranslate into greater heat storage during exercise in the heat in individualswith type 2 diabetes (T2D) compared with nondiabetic control (CON) subjects.
引言：2型糖尿病患者(T2D)与非糖尿病患者的控制组(CON)被试相比，在高温下运动期间，与糖尿病有关的局部皮肤血流量(SkBF)和出汗(LSR)减少是否使被动的热应激被转化为更多的蓄热尚不清楚
Purpose: Thisstudy aimed to examine the effects of T2D on whole-body heat exchange duringexercise in the heat.
研究目的：本研究目的是检验高温下运动期间2型糖尿病对全身热交换的影响。
Methods: Tenadults (6 males and 4 females) with T2D and 10 adults (6 males and 4 females)without diabetes matched for age, sex, body surface area, and body surface areaand aerobic fitness cycled continuously for 60 min at a fixed rate of metabolicheat production (~370 W) in a whole-body direct calorimeter (30°C and 20% relative humidity). Upper back LSR, forearmSkBF, rectal temperature, and heart rate were measured continuously. Whole-bodyheat loss and changes in body heat content (△Hb) were determined using simultaneous directwhole-body and indirect calorimetry.
研究方法：10名患2型糖尿病的成年人（6名男性和4名女性）和10名未患2型糖尿病的成年人（6名男性和4名女性），他们的年龄，性别，体表面积相匹配，并且使用全身直接热量计(30°C 和20%相对湿度)测量，以一个固定的新陈代谢产热(约370 W)，连续60分钟有氧骑功率车。持续测量上背部的出汗量，前臂的皮肤血流量，直肠温度和心率。通过同步直接和间接热量测定，决定全身热损耗和全身热含量的改变(△Hb)
Results: Whole-bodyheat loss was significantly attenuated from 15 min throughout the remainingexercise with the differences becoming more pronounced over time for T2Drelative to CON (P = 0.004). This resulted in a significantly greater △Hb in T2D (367±35; CON, 238±25 kJ, P =0.002). No differences were measured during recovery (T2D, -79±23; CON, -132±23 kJ, P =0.083). By the end of the 60-min recovery, the T2D group lost only 21% (79 kJ)of the total heat gained during exercise, whereas their nondiabeticcounterparts lost in excess of 55% (131 kJ). No difference were observed inLSR, SkBF, rectal temperature or heart rate during exercise. Similarly, no differenceswere measured during recovery with the exception that heart rate was elevatedin the T2D group relative to CON (p=0.004).
研究结果：2型糖尿病组与相比，从15分钟起一直到运动结束全身热损耗显著减少，并且随着时间推移差异更加明显(P = 0.004)。这导致了2型糖尿病组的△Hb明显较大(367±35; 控制组, 238±25 kJ, P =0.002)。恢复期没有差异(2型糖尿病组, -79±23; 控制组, -132±23 kJ, P =0.083)。60分钟恢复结束后，2型糖尿病组只丢失运动期间全部热增量的21% (79 kJ)，而非糖尿病组对应受试者的热丢失达到55% (131 kJ)。运动时测得的出汗量，皮肤血流量，直肠温度和心率没有差异。相似的，恢复期除了2型糖尿病组心率高于控制组(p=0.004)外，其余指标没有差异。
Conclusion: Olderadults with T2D have a reduced capacity to dissipate heat during exercise,resulting in a greater heat storage and therefore level of thermal strain.
研究结论：患2型糖尿病的老年人运动时的散热能力下降，导致较多的蓄热和较高的热应变水平。
Key Words: AGING,CHRONIC DISEASE, HEAT STRESS, CALORIMETRY, CHANGE IN BODY HEAT CONTENT, CORETEMPERATURE
关键词：衰老，慢性疾病，热应激，热量测定，身体热含量的改变，核心温度