肥胖荷尔蒙与骨质疏松的关系

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Correlation between Obesity Hormones and Osteoporosis
Date:  Dec. 28, 2011


New research from the University of Gothenburg’s Sahlgrenska Academy reveals that obesity-related hormones, specifically adiponectin, appear to be linked to osteoporosis and an increased risk of fractures. The researchers have seemingly found a connection between elevated levels of serum adiponectin and more fragile skeletal structures as well as reduced muscle strength and mass. In summary, the obesity-related hormone appears to be related to accelerated functional ageing. Dan Mellström, a researcher at the Sahlgrenska Academy, consultant at Sahlgrenska University Hospital, and leading expert in osteoporosis states, “High levels of adiponectin in the elderly seem to be associated with both reduced functioning of the musculature and a more fragile skeleton.” He goes on to explain that this essentially results in a higher risk of fractures and falls, as well as increased mortality. Dan is part of an international research project focusing on the study of osteoporosis-related risk factors in elderly men. The team is currently investigating the relationship between adiponectin and skeletal structure integrity. The current findings are based off of a study that includes approximately 11,000 men from Sweden, the USA, and Hong Kong. It must be recognized that the skeleton in itself is an active organ in constant communication with the brain via neuroendocrine-related pathways. Any organ that can produce systemic hormonal changes can have an impact on metabolic and structural integrity throughout the various systems of the body. For example, stem cells formed in the skeleton are home to hormones that control blood sugar and obesity by sending signals to various other organs. Considering the numerous endocrine-related functions of the skeleton, further research may shed additional light on the mechanisms by which it can modify the potential risk for disease-related risk factors.



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