髓母细胞瘤的3.0T 1H 磁共振波谱和扩散加权成像分析

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髓母细胞瘤的3.0T 1H 磁共振波谱和扩散加权成像分析





作者：EurekAlert!中文 来源：EurekAlert!中文 2012-12-13 16:34:54
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关键词： 髓母细胞瘤核磁共振波谱


髓母细胞瘤患者小脑蚓部促结蹄组织增生性MB伴鞍上池脑脊液转移. 方块处代表选取体素和测量ADC值的感兴趣区，箭头所指代表鞍上池脑脊液转移病灶。

磁共振质子波谱成像是目前惟一无侵袭性检测活体代谢物信息及生化改变的方法，扩散加权成像能检测活体组织内水分子运动，二者结合能有效评估髓母细胞瘤的组织学特性及其生物学行为，相关研究报道较少。一项关于“1H magnetic resonance spectroscopy and diffusion weighted imaging findings of medulloblastoma in 3.0T MRI ”的研究回顾性分析17例经病理证实髓母细胞瘤患者的3.0T磁共振影像特征。结果证实，髓母细胞瘤患者具有磁共振波谱特征性牛磺酸峰，且表观扩散系数较低。相关研究成果发表在《中国神经再生研究（英文版）》杂志于2012年11月32期出版的杂志上。(生物谷Bioon.com)


10.3969/j.issn.1673-5374.2012.32.011
PMC:
PMID:
1H magnetic resonance spectroscopy and diffusion weighted imaging findings of medulloblastoma in 3.0T MRI A retrospective analysis of 17 cases
Guangyao Wu, Haopeng Pang, Prasanna Ghimire, Guobing Liu

1H magnetic resonance spectroscopy and diffusion weighted imaging features of the cerebellar vermis in 17 medulloblastoma patients were retrospectively analyzed, and 17 healthy volunteers were selected as controls. 1H magnetic resonance spectroscopy showed that in all 17 medulloblastoma patients, N-acetyl aspartate and creatine peaks were significantly decreased, the choline peak was significantly increased, and there was evidence of a myo-inositol peak. Further, 11 patients showed a low taurine peak at 3.4 ppm, five patients showed a lipid peak at 0.9–1.3 ppm, and three patients showed a negative lactic acid peak at 1.33 ppm. Compared with the control group, the ratios of N-acetyl aspartate/choline and N-acetyl aspartate/creatine were significantly decreased, and the ratio of choline/creatine was increased, in medulloblastoma patients. Diffusion weighted imaging displayed hyperintensity and decreased apparent diffusion coefficient in medulloblastoma patients. These findings indicate that 1H magnetic resonance spectroscopy and diffusion weighted imaging are useful for qualitative diagnosis of medulloblastoma.